Novartis Institutes for Biomedical Research specializes in research for oncology, ophthalmology, cardiovascular and metabolic-related diseases, and has a significant presence in the biomedical research world. 250 Mass Ave is a combination of laboratory, vivarium, and office space.

Periodic third party performance verification is required to maintain high-performing facilities that support their research and ensure industry accreditations. Thus, Novartis hired Cornerstone to check their 250 Mass Ave facilities in order to verify approved performance. Incremental change in space, however, uses and operation of the systems over time can adversely impact facility performance required for this critical application. This verification process included but was not limited to verifying space pressurizations, directional airflow, pressure mapping, proper function of animal room air-direction indicators, temperature, relative humidity, air-change rates and associated room volumes, system airflows and BAS calculations.